CONFERENCE AGENDA

Day Two - May 3, 2024

Continental Breakfast

Chairperson's Opening Remarks

Andreas Jeromin, Ph.D., Chief Scientific Officer, ALZ Path

Improving TBI Outcomes Track - Track Chair's Opening Remarks

Kristen Dams-O'Connor, Ph.D., Vice Chair of Research, Director, Brain Injury Research Center, Icahn School of Medicine at Mount Sinai

Substance Use following Traumatic Brain Injury: Evidence of Substance Use Treatment Disparities and Adverse Consequences

Dr. Adams will provide a brief overview of the risk for excessive substance use following traumatic brain injury (TBI). In the context of the opioid and overdose epidemic, she will describe the "perfect storm" theory which posits that numerous risk factors may converge for people with TBI, placing them at increased risk for opioid use, misuse, substance use treatment disparities, and devastating consequences. Dr. Adams will highlight new studies which found that among people with opioid use disorder, people with a history of TBI experienced substance use treatment disparities compared to people without TBI, revealing health inequities. She will conclude her talk by synthesizing evidence for risk for adverse morbidity and mortality following TBI among people with substance use disorders.

Rachel Sayko Adams, Ph.D., MPH, Research Associate Professor, Dept. of Health, Law, Policy & Management, Boston University School of Public Health

Sex-specific Associations Between Traumatic Brain Injury and Non-fatal Drug Overdose in Young Adult Post-9/11 Veterans

Evidence is mounting that veterans with a history of traumatic brain injury (TBI) have a disproportionately higher risk for overdose, yet information on sex-specific associations is lacking. The present study evaluated whether there are sex-specific differences in the association between TBI and non-fatal overdose in a national prospective cohort of US post-9/11 veterans receiving care at the Department of Veterans Affairs. We examined two overdose outcomes; any drug overdose, and the subset of drug overdoses that were opioid-related. Furthermore, we estimated both the multiplicative and additive interactions between TBI and sex. Finally, we determined whether psychiatric disorders (posttraumatic stress disorder, mood disorders, and anxiety disorders) and substance use disorders (alcohol use disorder, opioid use disorder, and other substance use disorder) mediated the sex-specific association between TBI and each overdose outcome.

Jennifer Fonda, Ph.D., Assistant Professor, Chobanian & Avedisian School of Medicine, Department of Psychiatry, Boston University

Making Sense of Conflicting Narratives About Traumatic Brain Injury Outcomes

As the scientific literature on TBI grows, so does the diversity of research findings that appear to reach conflicting conclusions about the natural history of clinical recovery. For example, studies of “mild” TBI have reported both that recovery is almost always rapid and complete and that there is a high prevalence of long-term consequences of injury. Dr. Nelson will summarize findings from recent large, prospective studies of TBI on the early and long-term consequences of injury, including what we now know about the factors that explain variable patient outcomes and priority areas for future research.

Lindsay Nelson, Ph.D., ABPP, Associate Professor and Director of Translational Research, Department of Neurosurgery, Medical College of Wisconsin

Track Follow Up Discussion & Question/Answer Session

Refreshment Break/Exhibit Viewing/Poster Session

Clinical Research Track - Track Chair's Opening Remarks

Ramon Diaz-Arrastia, MD, Ph.D., John McCrea Dickson M.D. Presidential Professor, Department of Neurology, University of Pennsylvania

Spreading Depolarizations: a Clinical Target for Neuroprotection?

Dr. Hartings will review the pathophysiology of spreading depolarizations, their occurrence in the human brain after severe injury, and how they are measured by electrocorticography. He will review evidence from observational studies that depolarizations are a mechanism of secondary injury associated with worse outcomes. Finally, he will review current thoughts on treatments and how depolarization monitoring might allow a precision-medicine approach to neuroprotection.

Jed Hartings, Ph.D., Professor, Department of Neurosurgery, University of Cincinnati

Presentation Title to be Announced

Andrew Pieper, MD, Ph.D., Professor, Department of Neurosciences, Investigator, Case Western Reserve University, Harrington Discovery Institute

Presentation Title to be Announced

Track Follow Up Discussion & Question/Answer Session

Luncheon

Brain Injury & Neurodegeneration Research Track -Track Chair's Opening Remarks

Neil Graham, MD, Clinical Lecturer, Faculty of Medicine, Department of Brain Sciences, Imperial College London

Patterns of Traumatic Brain Injury-Related Cognitive Decline and Dementia: Insights from Epidemiology

Traumatic brain injury (TBI) is common and is associated with significant morbidity and mortality, especially among older individuals. In this presentation, the current epidemiology of traumatic brain injury will be presented. Leveraging data with over 30 years of follow-up, data presented herein will quantify the population-level burden of TBI and the dose-dependent long-term consequences of TBI (including data on cognitive decline and dementia risk) in comprehensive manner. Data will also be presented showing how epidemiological study design and biostatistical methods can provide insights into mechanisms underlying observed associations. The robust and dose-dependent associations of TBI with adverse outcomes underscore the importance of public health measures aimed at preventing head injuries and targeted clinical interventions to reduce morbidity and mortality after head injury.

Andrea Schneider, MD, Ph.D., Assistant Professor, Department of Neurology, Division of Neurocritical Care, University of Pennsylvania School of Medicine

The Spectrum of Downstream Neurodegenerative and Clinical Outcomes of Repetitive Head Trauma

Exposure to repetitive head impacts (RHI) from activities like contact/collision sports, military service, assaults, and other sources increases the risk for later-life neurodegenerative disease. Patterns have begun to emerge linking RHI to certain diseases and types of symptoms, some of which seem highly specific to prior RHI while others more commonly are described in individuals without known RHI. This presentation will discuss how the combination of fluid biomarkers, neuroimaging, and a thorough clinical assessment can help inform the presence of a neurodegenerative condition and the likelihood that prior RHI has played a role in current brain health.

Breton Asken, Ph.D., ATC, Assistant Professor, Department of Clinical and Health Psychology, University of Florida

Presentation Title to be Announced

Raquel Gardner, MD, Principal Investigator and Director of Clinical Research, Joseph Sagol Neuroscience Center, Sheba Medical Center

Presentation Title to be Announced

Track Follow Up Discussion & Question/Answer Session

End of Conference

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